HIV Target gene Detail Information

> CYB5R3 Gene Search Result

Gene Information

Gene Name	CYB5R3
Gene ID	1727
Gene Full Name	cytochrome b5 reductase 3
Gene Alias	B5R; DIA1
Transcripts	ENSG00000100243
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P00387
HGNC ID	HGNC:2873
VEGA ID	OTTHUMG00000150745
OMIM ID	613213
String ID	9606.ENSP00000354468
Drugbank ID	BE0000160
PharmGKB ID	PA27331

Target gene [CYB5R3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008428	chr22	12	3		15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CYB5R3 expression and immune infiltrating cell level correlation result in HIV+ samples
CYB5R3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CYB5R3 expression and immune infiltrating cell level correlation result in HIV+ samples
CYB5R3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).