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HTLV1 Target gene Detail Information

> CXCR4 Gene Search Result


Gene Information
Gene Name CXCR4
Gene ID 7852
Gene Full Name C-X-C motif chemokine receptor 4
Gene Alias FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
Transcripts ENSG00000121966
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Gene Function Oncogene
Uniport_ID P61073
HGNC ID HGNC:2561
VEGA ID OTTHUMG00000153583
OMIM ID 162643
String ID 9606.ENSP00000386884
Drugbank ID BE0000919
PharmGKB ID PA27058
Target gene [CXCR4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001918 chr2 300 16 316 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CXCR4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CXCR4 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CXCR4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CXCR4 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CXCR4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CXCR4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).