HPV Target gene Detail Information

> CXCL6 Gene Search Result

Gene Information

Gene Name	CXCL6
Gene ID	6372
Gene Full Name	C-X-C motif chemokine ligand 6
Gene Alias	GCP2; CKA-3; GCP-2; SCYB6
Transcripts	ENSG00000124875
Virus	HPV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted secreted proteins
Uniport_ID	P80162
HGNC ID	HGNC:10643
VEGA ID	OTTHUMG00000130010
OMIM ID	138965
String ID	9606.ENSP00000226317
PharmGKB ID	PA35574

Target gene [CXCL6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402651	chr4	36	6	7	49	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of CXCL6 expression and immune infiltrating cell level correlation result in HPV+ samples
CXCL6 expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of CXCL6 expression and immune infiltrating cell level correlation result in HPV+ samples
CXCL6 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of CXCL6 expression and immune infiltrating cell level correlation result in HPV+ samples
CXCL6 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of CXCL6 expression and immune infiltrating cell level correlation result in HPV+ samples
CXCL6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).