HTLV1 Target gene Detail Information

> CUX2 Gene Search Result

Gene Information

Gene Name	CUX2
Gene ID	23316
Gene Full Name	cut like homeobox 2
Gene Alias	CDP2; CUTL2; EIEE67
Transcripts	ENSG00000111249
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Uniport_ID	O14529
HGNC ID	HGNC:19347
VEGA ID	OTTHUMG00000169546
OMIM ID	610648
String ID	9606.ENSP00000261726
PharmGKB ID	PA162382977

Target gene [CUX2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007862	chr12	39	11	1	51	View
6009280	chr12	31	5	2	38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CUX2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CUX2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CUX2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CUX2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).