HIV Target gene Detail Information

> CTSB Gene Search Result

Gene Information

Gene Name	CTSB
Gene ID	1508
Gene Full Name	cathepsin B
Gene Alias	APPS; CPSB; RECEUP
Transcripts	ENSG00000285132
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;Nucleoli;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P07858
HGNC ID	HGNC:2527
VEGA ID	OTTHUMG00000090799
OMIM ID	116810
String ID	9606.ENSP00000345672
Drugbank ID	BE0000939
PharmGKB ID	PA27027

Target gene [CTSB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000591	chr8	23	178	158	359	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CTSB expression and immune infiltrating cell level correlation result in HIV+ samples
CTSB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CTSB expression and immune infiltrating cell level correlation result in HIV+ samples
CTSB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).