HIV Target gene Detail Information

> CS Gene Search Result

Gene Information

Gene Name	CS
Gene ID	1431
Gene Full Name	citrate synthase
Transcripts	ENSG00000062485
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O75390
HGNC ID	HGNC:2422
VEGA ID	OTTHUMG00000170344
OMIM ID	118950
String ID	9606.ENSP00000342056
Drugbank ID	BE0004459
PharmGKB ID	PA26928

Target gene [CS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001778	chr12	66	62	5	133	View
4003109	chr12	69			69	View
4007901	chr12	7	10		17	View
4008330	chr12	13	2		15	View
4009261	chr4	7	5		12	View
4014441	chr21		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CS expression and immune infiltrating cell level correlation result in HIV+ samples
CS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CS expression and immune infiltrating cell level correlation result in HIV+ samples
CS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).