HIV Target gene Detail Information

> CRTC3 Gene Search Result

Gene Information

Gene Name	CRTC3
Gene ID	64784
Gene Full Name	CREB regulated transcription coactivator 3
Gene Alias	TORC3; TORC-3
Transcripts	ENSG00000140577
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Uniport_ID	Q6UUV7
HGNC ID	HGNC:26148
VEGA ID	OTTHUMG00000172295
OMIM ID	608986
String ID	9606.ENSP00000268184
PharmGKB ID	PA142672074

Target gene [CRTC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000432	chr15	309	52	105	466	View
4001341	chr15	61	46	69	176	View
4001528	chr15	144	10		154	View
4004798	chr15	4	35		39	View
4006949	chr15	16	4	2	22	View
4006984	chr15	20	1		21	View
4010111	chr15	6	3	1	10	View
4011981	chr15	3	3		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CRTC3 expression and immune infiltrating cell level correlation result in HIV+ samples
CRTC3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CRTC3 expression and immune infiltrating cell level correlation result in HIV+ samples
CRTC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).