HIV Target gene Detail Information

> CRKL Gene Search Result

Gene Information

Gene Name	CRKL
Gene ID	1399
Gene Full Name	CRK like proto-oncogene, adaptor protein
Transcripts	ENSG00000099942
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P46109
HGNC ID	HGNC:2363
VEGA ID	OTTHUMG00000150807
OMIM ID	602007
String ID	9606.ENSP00000346300
PharmGKB ID	PA26881

Target gene [CRKL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008256	chr22	13	2	1	16	View
4015537	chr22	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CRKL expression and immune infiltrating cell level correlation result in HIV+ samples
CRKL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CRKL expression and immune infiltrating cell level correlation result in HIV+ samples
CRKL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).