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HBV Target gene Detail Information

> CREB1 Gene Search Result


Gene Information
Gene Name CREB1
Gene ID 1385
Gene Full Name cAMP responsive element binding protein 1
Gene Alias CREB; CREB-1
Transcripts ENSG00000118260
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function Oncogene
Uniport_ID P16220
HGNC ID HGNC:2345
VEGA ID OTTHUMG00000132936
OMIM ID 123810
String ID 9606.ENSP00000387699
Drugbank ID BE0000958
PharmGKB ID PA26864
Target gene [CREB1] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29609638 A181T
RT
 View

Target gene [CREB1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1400453 chr2 15 240 13 268 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of CREB1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CREB1 expression: Low -> High
Lollipop of CREB1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of CREB1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of CREB1 expression and immune infiltrating cell level correlation result in HBV+ samples
CREB1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).