HIV Target gene Detail Information

> CPSF6 Gene Search Result

Gene Information

Gene Name	CPSF6
Gene ID	11052
Gene Full Name	cleavage and polyadenylation specific factor 6
Gene Alias	CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7
Transcripts	ENSG00000111605
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q16630
HGNC ID	HGNC:13871
VEGA ID	OTTHUMG00000169340
OMIM ID	604979
String ID	9606.ENSP00000266679
PharmGKB ID	PA26846

Target gene [CPSF6] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	24415937	Q219A	CA	R	View
2	24415937	R143A	CA	R	View
3	24415937	L136M	CA	R	View
4	24415937	R132A	CA	R	View
5	24415937	R132K	CA	R	View
6	24415937	E128A	CA	R	View
7	24415937	Q112H	CA	R	View
8	24415937	T107A	CA	R	View
9	24415937	T107I	CA	R	View
10	24415937	G94D	CA	R	View
11	24415937	A92E	CA	R	View
12	24415937	A92V	CA	R	View
13	24415937	P90A	CA	R	View
14	24415937	V86A	CA	R	View
15	24415937	N74D	CA	R	View
16	24415937	E71A	CA	R	View
17	24415937	Q67A	CA	R	View
18	24415937	Q63A	CA	R	View
19	24415937	T54A	CA	R	View
20	24415937	E45A	CA	R	View
21	24415937	P38A	CA	R	View
22	24415937	A105T	CA	R	View

Target gene [CPSF6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4012013	chr12	2	3		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CPSF6 expression and immune infiltrating cell level correlation result in HIV+ samples
CPSF6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE17372