HIV Target gene Detail Information

> COX10 Gene Search Result

Gene Information

Gene Name	COX10
Gene ID	1352
Gene Full Name	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Transcripts	ENSG00000006695
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;Nucleoli;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q12887
HGNC ID	HGNC:2260
VEGA ID	OTTHUMG00000058814
OMIM ID	602125
String ID	9606.ENSP00000261643
PharmGKB ID	PA26776

Target gene [COX10] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000849	chr17	215	46	5	266	View
4004033	chr17	19	19	12	50	View
4005051	chr17	34	2		36	View
4013625	chr17	3			3	View
4013871	chr17		3		3	View
4014154	chr17			2	2	View
4015302	chr17	1			1	View
4015303	chr17	1			1	View
4016085	chr17				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of COX10 expression and immune infiltrating cell level correlation result in HIV+ samples
COX10 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of COX10 expression and immune infiltrating cell level correlation result in HIV+ samples
COX10 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).