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HTLV1 Target gene Detail Information

> COMT Gene Search Result


Gene Information
Gene Name COMT
Gene ID 1312
Gene Full Name catechol-O-methyltransferase
Gene Alias HEL-S-98n
Transcripts ENSG00000093010
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P21964
HGNC ID HGNC:2228
VEGA ID OTTHUMG00000150529
OMIM ID 116790
String ID 9606.ENSP00000354511
Drugbank ID BE0002089
PharmGKB ID PA117
Target gene [COMT] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6009284 chr22 32 6 38 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of COMT expression and immune infiltrating cell level correlation result in HTLV1+ samples
COMT expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of COMT expression and immune infiltrating cell level correlation result in HTLV1+ samples
COMT expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of COMT expression and immune infiltrating cell level correlation result in HTLV1+ samples
COMT expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).