HBV Target gene Detail Information

> COL4A4 Gene Search Result

Gene Information

Gene Name	COL4A4
Gene ID	1286
Gene Full Name	collagen type IV alpha 4 chain
Gene Alias	CA44
Transcripts	ENSG00000081052
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P53420
HGNC ID	HGNC:2206
VEGA ID	OTTHUMG00000149892
OMIM ID	120131
String ID	9606.ENSP00000379866
Drugbank ID	BE0003498
PharmGKB ID	PA26721

Target gene [COL4A4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002093	chr2	215	38	95	348	View
1006413	chr2	1	4	33	38	View
1019508	chr2				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of COL4A4 expression and immune infiltrating cell level correlation result in HBV+ samples
COL4A4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).