HTLV1 Target gene Detail Information

> COL2A1 Gene Search Result

Gene Information

Gene Name	COL2A1
Gene ID	1280
Gene Full Name	collagen type II alpha 1 chain
Gene Alias	AOM; ANFH; SEDC; STL1; COL11A3
Transcripts	ENSG00000139219
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted secreted proteins
Uniport_ID	P02458
HGNC ID	HGNC:2200
VEGA ID	OTTHUMG00000149896
OMIM ID	120140
String ID	9606.ENSP00000369889
Drugbank ID	BE0002140; BE0002141
PharmGKB ID	PA26715

Target gene [COL2A1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001024	chr12	327	122	189	638	View
6001025	chr12	327	122	189	638	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of COL2A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
COL2A1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of COL2A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
COL2A1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of COL2A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
COL2A1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).