HTLV1 Target gene Detail Information

> CNKSR3 Gene Search Result

Gene Information

Gene Name	CNKSR3
Gene ID	154043
Gene Full Name	CNKSR family member 3
Gene Alias	CNK3; MAGI1; CNK3/IPCEF1
Transcripts	ENSG00000153721
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q6P9H4
HGNC ID	HGNC:23034
VEGA ID	OTTHUMG00000015873
OMIM ID	617476
String ID	9606.ENSP00000475915
PharmGKB ID	PA134880153

Target gene [CNKSR3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003424	chr6	89	25	47	161	View
6009122	chr6	8	16	15	39	View
6009381	chr6	12	6	19	37	View
6009474	chr6	11	13	13	37	View
6010414	chr6	28	3		31	View
6026671	chr6		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CNKSR3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CNKSR3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CNKSR3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CNKSR3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of CNKSR3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CNKSR3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).