Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> CLK4 Gene Search Result


Gene Information
Gene Name CLK4
Gene ID 57396
Gene Full Name CDC like kinase 4
Transcripts ENSG00000113240
Virus HBV
Gene Type protein coding
HPA Location Info Actin filaments;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q9HAZ1
HGNC ID HGNC:13659
VEGA ID OTTHUMG00000130893
OMIM ID 607969
String ID 9606.ENSP00000316948
Drugbank ID BE0009380
Drug (Cytoscape Annotation) Sunitinib Malate
PharmGKB ID PA26598
Target gene [CLK4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006477 chr5 34 4 38 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of CLK4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CLK4 expression: Low -> High
Lollipop of CLK4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of CLK4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of CLK4 expression and immune infiltrating cell level correlation result in HBV+ samples
CLK4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).