HIV Target gene Detail Information

> CKLF Gene Search Result

Gene Information

Gene Name	CKLF
Gene ID	51192
Gene Full Name	chemokine like factor
Gene Alias	C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224
Transcripts	ENSG00000217555
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q9UBR5
HGNC ID	HGNC:13253
VEGA ID	OTTHUMG00000137504
OMIM ID	616074
String ID	9606.ENSP00000264001
PharmGKB ID	PA26531

Target gene [CKLF] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007504	chr16	17	2		19	View
4008533	chr16	15			15	View
4009142	chr16	11	1		12	View
4012724	chr16	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CKLF expression and immune infiltrating cell level correlation result in HIV+ samples
CKLF expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CKLF expression and immune infiltrating cell level correlation result in HIV+ samples
CKLF expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).