HIV Target gene Detail Information

> CIC Gene Search Result

Gene Information

Gene Name	CIC
Gene ID	23152
Gene Full Name	capicua transcriptional repressor
Gene Alias	MRD45
Transcripts	ENSG00000079432
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q96RK0
HGNC ID	HGNC:14214
VEGA ID	OTTHUMG00000182794
OMIM ID	612082
String ID	9606.ENSP00000458663
PharmGKB ID	PA26513

Target gene [CIC] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005336	chr19	30	4		34	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CIC expression and immune infiltrating cell level correlation result in HIV+ samples
CIC expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CIC expression and immune infiltrating cell level correlation result in HIV+ samples
CIC expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).