HIV Target gene Detail Information

> CHUK Gene Search Result

Gene Information

Gene Name	CHUK
Gene ID	1147
Gene Full Name	conserved helix-loop-helix ubiquitous kinase
Gene Alias	IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha
Transcripts	ENSG00000213341
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Suppressor gene
Uniport_ID	O15111
HGNC ID	HGNC:1974
VEGA ID	OTTHUMG00000018899
OMIM ID	600664
String ID	9606.ENSP00000359424
Drugbank ID	BE0004655
PharmGKB ID	PA26510

Target gene [CHUK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005440	chr10	23	8	1	32	View
4008564	chr10	9	1	4	14	View
4010665	chr10	8			8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CHUK expression and immune infiltrating cell level correlation result in HIV+ samples
CHUK expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CHUK expression and immune infiltrating cell level correlation result in HIV+ samples
CHUK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).