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HPV Target gene Detail Information

> CHRNA2 Gene Search Result


Gene Information
Gene Name CHRNA2
Gene ID 1135
Gene Full Name cholinergic receptor nicotinic alpha 2 subunit
Transcripts ENSG00000120903
Virus HPV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q15822
HGNC ID HGNC:1956
VEGA ID OTTHUMG00000102083
OMIM ID 118502
String ID 9606.ENSP00000385026
Drugbank ID BE0000738; BE0009927
PharmGKB ID PA26489
Target gene [CHRNA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5000996 chr8 45 5 10 60 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of CHRNA2 expression and immune infiltrating cell level correlation result in HPV+ samples
CHRNA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).