HIV Target gene Detail Information

> CHKA Gene Search Result

Gene Information

Gene Name	CHKA
Gene ID	1119
Gene Full Name	choline kinase alpha
Gene Alias	CK; EK; CHK; CKI
Transcripts	ENSG00000110721
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	P35790
HGNC ID	HGNC:1937
VEGA ID	OTTHUMG00000167424
OMIM ID	118491
String ID	9606.ENSP00000265689
Drugbank ID	BE0000784
PharmGKB ID	PA26468

Target gene [CHKA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005751	chr11	6	9	15	30	View
4006865	chr11	12	10		22	View
4008661	chr11	12	2		14	View
4014337	chr11	2			2	View
4100033	chr11	37		1	38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CHKA expression and immune infiltrating cell level correlation result in HIV+ samples
CHKA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CHKA expression and immune infiltrating cell level correlation result in HIV+ samples
CHKA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).