HTLV1 Target gene Detail Information

> CHFR Gene Search Result

Gene Information

Gene Name	CHFR
Gene ID	55743
Gene Full Name	checkpoint with forkhead and ring finger domains
Gene Alias	RNF116; RNF196
Transcripts	ENSG00000072609
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;Nuclear bodies;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q96EP1
HGNC ID	HGNC:20455
VEGA ID	OTTHUMG00000167930
OMIM ID	605209
String ID	9606.ENSP00000392395
PharmGKB ID	PA134898949

Target gene [CHFR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002183	chr12	199	41	33	273	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CHFR expression and immune infiltrating cell level correlation result in HTLV1+ samples
CHFR expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CHFR expression and immune infiltrating cell level correlation result in HTLV1+ samples
CHFR expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of CHFR expression and immune infiltrating cell level correlation result in HTLV1+ samples
CHFR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).