HIV Target gene Detail Information

> CHEK1 Gene Search Result

Gene Information

Gene Name	CHEK1
Gene ID	1111
Gene Full Name	checkpoint kinase 1
Gene Alias	CHK1
Transcripts	ENSG00000149554
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O14757
HGNC ID	HGNC:1925
VEGA ID	OTTHUMG00000165853
OMIM ID	603078
String ID	9606.ENSP00000388648
Drugbank ID	BE0003382
PharmGKB ID	PA110

Target gene [CHEK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011437	chr11		7		7	View
4012870	chr11	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CHEK1 expression and immune infiltrating cell level correlation result in HIV+ samples
CHEK1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CHEK1 expression and immune infiltrating cell level correlation result in HIV+ samples
CHEK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).