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HBV Target gene Detail Information

> CFH Gene Search Result


Gene Information
Gene Name CFH
Gene ID 3075
Gene Full Name complement factor H
Gene Alias FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3
Transcripts ENSG00000000971
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID P08603
HGNC ID HGNC:4883
VEGA ID OTTHUMG00000035607
OMIM ID 134370
String ID 9606.ENSP00000356399
Drugbank ID BE0008978; BE0009053
PharmGKB ID PA29261
Target gene [CFH] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001035 chr1 56 629 431 1116 View
1006344 chr1 31 9 40 View
1007248 chr1 20 9 29 View
1016759 chr1 1 1 View
1018081 chr1 0 View
1404506 chr1 15 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of CFH expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CFH expression: Low -> High
Lollipop of CFH expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of CFH expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of CFH expression and immune infiltrating cell level correlation result in HBV+ samples
CFH expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).