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HBV Target gene Detail Information

> CDKAL1 Gene Search Result


Gene Information
Gene Name CDKAL1
Gene ID 54901
Gene Full Name CDK5 regulatory subunit associated protein 1 like 1
Transcripts ENSG00000145996
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q5VV42
HGNC ID HGNC:21050
VEGA ID OTTHUMG00000014340
OMIM ID 611259
String ID 9606.ENSP00000274695
PharmGKB ID PA134871999
Target gene [CDKAL1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002363 chr6 11 174 102 287 View
1003156 chr6 47 70 43 160 View
1003388 chr6 96 40 2 138 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of CDKAL1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CDKAL1 expression: Low -> High
Lollipop of CDKAL1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of CDKAL1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of CDKAL1 expression and immune infiltrating cell level correlation result in HBV+ samples
CDKAL1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).