HTLV1 Target gene Detail Information

> CDC25A Gene Search Result

Gene Information

Gene Name	CDC25A
Gene ID	993
Gene Full Name	cell division cycle 25A
Gene Alias	CDC25A2
Transcripts	ENSG00000164045
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Golgi apparatus;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P30304
HGNC ID	HGNC:1725
VEGA ID	OTTHUMG00000133535
OMIM ID	116947
String ID	9606.ENSP00000303706
PharmGKB ID	PA26259

Target gene [CDC25A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6005806	chr3	78	1	1	80	View
6018156	chr3	8	1		9	View
6023165	chr3	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CDC25A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CDC25A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CDC25A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CDC25A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of CDC25A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CDC25A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).