HIV Target gene Detail Information

> CD44 Gene Search Result

Gene Information

Gene Name	CD44
Gene ID	960
Gene Full Name	CD44 molecule (Indian blood group)
Gene Alias	IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
Transcripts	ENSG00000026508
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Golgi apparatus;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Blood group antigen proteins, Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Gene Function	Suppressor gene
Uniport_ID	P16070
HGNC ID	HGNC:1681
VEGA ID	OTTHUMG00000044388
OMIM ID	107269
String ID	9606.ENSP00000398632
Drugbank ID	BE0001113
PharmGKB ID	PA26221

Target gene [CD44] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005083	chr11	9	15	12	36	View
4005551	chr11	23	8		31	View
4014670	chr11	1		1	2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CD44 expression and immune infiltrating cell level correlation result in HIV+ samples
CD44 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CD44 expression and immune infiltrating cell level correlation result in HIV+ samples
CD44 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).