HIV Target gene Detail Information

> CD4 Gene Search Result

Gene Information

Gene Name	CD4
Gene ID	920
Gene Full Name	CD4 molecule
Gene Alias	CD4mut
Transcripts	ENSG00000010610
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	P01730
HGNC ID	HGNC:1678
VEGA ID	OTTHUMG00000168514
OMIM ID	186940
String ID	9606.ENSP00000011653
Drugbank ID	BE0003488
PharmGKB ID	PA26220

Target gene [CD4] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	25174000	Y435A	Gp120	C	View
2	25174000	M434A	Gp120	C	View
3	25174000	N197S	Gp120	C	View
4	25174000	L193A	Gp120	C	View
5	25174000	N188A	Gp120	C	View
6	25174000	N156A	Gp120	C	View
7	25174000	I154A	Gp120	C	View
8	25174000	R440E	Gp120	C	View
9	25174000	E168K	Gp120	C	View
10	27992602	D368R	Gp120		View

Target gene [CD4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000444	chr10	264	111	85	460	View
4001830	chr10	125	3		128	View
4004400	chr12	17	23	5	45	View
4004530	chr12	15	23	5	43	View
4008921	chr12	12	1		13	View
4011650	chr12	6			6	View
4013425	chr12	2	1		3	View
4013840	chr10	3			3	View

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).