HIV Target gene Detail Information

> CD28 Gene Search Result

Gene Information

Gene Name	CD28
Gene ID	940
Gene Full Name	CD28 molecule
Gene Alias	Tp44
Transcripts	ENSG00000178562
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Predicted membrane proteins
Uniport_ID	P10747
HGNC ID	HGNC:1653
VEGA ID	OTTHUMG00000132878
OMIM ID	186760
String ID	9606.ENSP00000324890
PharmGKB ID	PA26207

Target gene [CD28] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001457	chr2	48	73	41	162	View
4005096	chr2	28	8		36	View
4012105	chr2	5			5	View
4015099	chr2	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CD28 expression and immune infiltrating cell level correlation result in HIV+ samples
CD28 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CD28 expression and immune infiltrating cell level correlation result in HIV+ samples
CD28 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).