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HPV Target gene Detail Information

> CD274 Gene Search Result


Gene Information
Gene Name CD274
Gene ID 29126
Gene Full Name CD274 molecule
Gene Alias B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
Transcripts ENSG00000120217
Virus HPV
Gene Type protein coding
HPA Location Info Actin filaments;Plasma membrane;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, FDA approved drug targets, Predicted membrane proteins
Uniport_ID Q9NZQ7
HGNC ID HGNC:17635
VEGA ID OTTHUMG00000019503
OMIM ID 605402
String ID 9606.ENSP00000370989
Drugbank ID BE0003441
PharmGKB ID PA134915280
FDA Approved Drug Atezolizumab;Avelumab;Durvalumab;Ipilimumab;Nivolumab;Pembrolizumab
Target gene [CD274] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5001151 chr9 15 33 48 View
5001750 chr9 18 4 2 24 View
5001857 chr9 15 4 2 21 View
5001859 chr9 15 4 2 21 View
5003058 chr9 5 1 6 View
5003214 chr9 5 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of CD274 expression and immune infiltrating cell level correlation result in HPV+ samples
CD274 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).