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HTLV1 Target gene Detail Information

> CD22 Gene Search Result


Gene Information
Gene Name CD22
Gene ID 933
Gene Full Name CD22 molecule
Gene Alias SIGLEC2; SIGLEC-2
Transcripts ENSG00000012124
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P20273
HGNC ID HGNC:1643
VEGA ID OTTHUMG00000183298
OMIM ID 107266
String ID 9606.ENSP00000085219
Drugbank ID BE0000183
PharmGKB ID PA26201
Target gene [CD22] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005933 chr19 67 10 1 78 View
6024185 chr19 4 4 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CD22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD22 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CD22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD22 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CD22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD22 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).