HIV Target gene Detail Information

> CCR2 Gene Search Result

Gene Information

Gene Name	CCR2
Gene ID	729230
Gene Full Name	C-C motif chemokine receptor 2
Gene Alias	CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
Transcripts	ENSG00000121807
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, G-protein coupled receptors, Predicted membrane proteins
Uniport_ID	P41597
HGNC ID	HGNC:1603
VEGA ID	OTTHUMG00000156466
OMIM ID	601267
String ID	9606.ENSP00000292301
Drugbank ID	BE0003387
PharmGKB ID	PA26167

Target gene [CCR2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001431	chr3	83	19	64	166	View
4003348	chr3	40	16	7	63	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CCR2 expression and immune infiltrating cell level correlation result in HIV+ samples
CCR2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CCR2 expression and immune infiltrating cell level correlation result in HIV+ samples
CCR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).