HBV Target gene Detail Information

> CCND1 Gene Search Result

Gene Information

Gene Name	CCND1
Gene ID	595
Gene Full Name	cyclin D1
Gene Alias	BCL1; PRAD1; U21B31; D11S287E
Transcripts	ENSG00000110092
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P24385
HGNC ID	HGNC:1582
VEGA ID	OTTHUMG00000167877
OMIM ID	168461
String ID	9606.ENSP00000227507
Drugbank ID	BE0001027
PharmGKB ID	PA75

Target gene [CCND1] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	25567052	G1764A	BCP	G	View
2	25567052	T1753A	BCP	G	View
3	29609638	A181T	RT		View

Target gene [CCND1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003535	chr11	108	18		126	View
1003844	chr11	89	21	5	115	View
1003979	chr11	91	7	1	99	View
1004047	chr11	91	7	1	99	View
1008916	chr11	18			18	View
1400639	chr11	5	3		8	View
1400793	chr11	108	18		126	View
1401407	chr11	18			18	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of CCND1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CCND1 expression: Low -> High
Lollipop of CCND1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of CCND1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of CCND1 expression and immune infiltrating cell level correlation result in HBV+ samples
CCND1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE114783