HIV Target gene Detail Information

> CCM2 Gene Search Result

Gene Information

Gene Name	CCM2
Gene ID	83605
Gene Full Name	CCM2 scaffold protein
Gene Alias	OSM; C7orf22; PP10187
Transcripts	ENSG00000136280
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9BSQ5
HGNC ID	HGNC:21708
VEGA ID	OTTHUMG00000129246
OMIM ID	607929
String ID	9606.ENSP00000370503
PharmGKB ID	PA26145

Target gene [CCM2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000713	chr7	121	117	69	307	View
4001080	chr7	135	60	24	219	View
4001747	chr7	67	45	23	135	View
4006500	chr7	24			24	View
4006512	chr7	17	7		24	View
4006547	chr7	13	11		24	View
4006709	chr7	11	12		23	View
4006762	chr7	23			23	View
4007934	chr7	15	2		17	View
4009784	chr7	10			10	View
4013224	chr7	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CCM2 expression and immune infiltrating cell level correlation result in HIV+ samples
CCM2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CCM2 expression and immune infiltrating cell level correlation result in HIV+ samples
CCM2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).