HPV Target gene Detail Information

> CBWD2 Gene Search Result

Gene Information

Gene Name	CBWD2
Gene ID	150472
Gene Full Name	COBW domain containing 2
Transcripts	ENSG00000136682
Virus	HPV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q8IUF1
HGNC ID	HGNC:17907
VEGA ID	OTTHUMG00000131360
OMIM ID	611079
String ID	9606.ENSP00000259199
PharmGKB ID	PA26125

Target gene [CBWD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5002533	chr2	10			10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of CBWD2 expression and immune infiltrating cell level correlation result in HPV+ samples
CBWD2 expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of CBWD2 expression and immune infiltrating cell level correlation result in HPV+ samples
CBWD2 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of CBWD2 expression and immune infiltrating cell level correlation result in HPV+ samples
CBWD2 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of CBWD2 expression and immune infiltrating cell level correlation result in HPV+ samples
CBWD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).