HIV Target gene Detail Information

> CBFB Gene Search Result

Gene Information

Gene Name	CBFB
Gene ID	865
Gene Full Name	core-binding factor subunit beta
Gene Alias	PEBP2B
Transcripts	ENSG00000067955
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q13951
HGNC ID	HGNC:1539
VEGA ID	OTTHUMG00000137520
OMIM ID	121360
String ID	9606.ENSP00000415151
PharmGKB ID	PA26114

Target gene [CBFB] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Detail
1	24418540	E88A	Vif	View
2	28302150	S52A	Vif	View
3	28302150	I51A	Vif	View
4	28302150	K50A	Vif	View
5	28302150	P49A	Vif	View
6	28302150	L24A	Vif	View
7	28302150	R23A	Vif	View
8	28302150	T20A	Vif	View
9	28302150	N19A	Vif	View
10	28302150	R17A	Vif	View
11	28302150	M16A	Vif	View
12	28302150	V13A	Vif	View
13	28302150	Q12A	Vif	View
14	28302150	W11A	Vif	View
15	28302150	M8A	Vif	View
16	28302150	V7A	Vif	View
17	28302150	R4A	Vif	View
18	28302150	N3A	Vif	View

Target gene [CBFB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000522	chr16	356	32	11	399	View
4000995	chr16	25	31	174	230	View
4001175	chr16	200			200	View
4001428	chr16	166	1		167	View
4003226	chr16	40	24	2	66	View
4004092	chr16	48	1		49	View
4004395	chr16	29	11	5	45	View
4004891	chr16	37	1		38	View
4005454	chr16	25	4	3	32	View
4006595	chr16	20	4		24	View
4009923	chr16	3	6	1	10	View
4010195	chr16		9		9	View
4011711	chr16	5	1		6	View
4012072	chr16	3	1	1	5	View
4013439	chr16	3			3	View
4013870	chr16	1	2		3	View
4013984	chr16	3			3	View
4100046	chr16	22	13	65	100	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CBFB expression and immune infiltrating cell level correlation result in HIV+ samples
CBFB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CBFB expression and immune infiltrating cell level correlation result in HIV+ samples
CBFB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE17372