HIV Target gene Detail Information

> CASP8 Gene Search Result

Gene Information

Gene Name	CASP8
Gene ID	841
Gene Full Name	caspase 8
Gene Alias	CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Transcripts	ENSG00000064012
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q14790
HGNC ID	HGNC:1509
VEGA ID	OTTHUMG00000132821
OMIM ID	601763
String ID	9606.ENSP00000351273
Drugbank ID	BE0003460
PharmGKB ID	PA26092

Target gene [CASP8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009562	chr2	5	3	3	11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CASP8 expression and immune infiltrating cell level correlation result in HIV+ samples
CASP8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CASP8 expression and immune infiltrating cell level correlation result in HIV+ samples
CASP8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).