HIV Target gene Detail Information

> CASP2 Gene Search Result

Gene Information

Gene Name	CASP2
Gene ID	835
Gene Full Name	caspase 2
Gene Alias	ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57
Transcripts	ENSG00000106144
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P42575
HGNC ID	HGNC:1503
VEGA ID	OTTHUMG00000023641
OMIM ID	600639
String ID	9606.ENSP00000312664
PharmGKB ID	PA26086

Target gene [CASP2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000091	chr7	69	796	300	1165	View
4012358	chr7	4		1	5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CASP2 expression and immune infiltrating cell level correlation result in HIV+ samples
CASP2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CASP2 expression and immune infiltrating cell level correlation result in HIV+ samples
CASP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).