HIV Target gene Detail Information

> CASK Gene Search Result

Gene Information

Gene Name	CASK
Gene ID	8573
Gene Full Name	calcium/calmodulin dependent serine protein kinase
Gene Alias	CMG; FGS4; LIN2; TNRC8; hCASK; CAGH39; CAMGUK; MICPCH; MRXSNA
Transcripts	ENSG00000147044
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O14936
HGNC ID	HGNC:1497
VEGA ID	OTTHUMG00000021378
OMIM ID	300172
String ID	9606.ENSP00000367408
Drugbank ID	BE0002641
PharmGKB ID	PA26081

Target gene [CASK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003327	chrX	10	51	3	64	View
4010525	chrX	7		1	8	View
4011299	chrX	6	1		7	View
4012143	chrX	2	3		5	View
4013760	chrX	3			3	View
4016784	chrX				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CASK expression and immune infiltrating cell level correlation result in HIV+ samples
CASK expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CASK expression and immune infiltrating cell level correlation result in HIV+ samples
CASK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).