HIV Target gene Detail Information

> CARD8 Gene Search Result

Gene Information

Gene Name	CARD8
Gene ID	22900
Gene Full Name	caspase recruitment domain family member 8
Gene Alias	NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Transcripts	ENSG00000105483
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9Y2G2
HGNC ID	HGNC:17057
VEGA ID	OTTHUMG00000165047
OMIM ID	609051
String ID	9606.ENSP00000375767
PharmGKB ID	PA134916154

Target gene [CARD8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001579	chr19	128	18	1	147	View
4003507	chr19	60			60	View
4003534	chr19	59			59	View
4005111	chr19	35	1		36	View
4005207	chr19	34	1		35	View
4007324	chr19	20			20	View
4008236	chr19	15	1		16	View
4008305	chr19	9	6		15	View
4010992	chr19	6	1		7	View
4010993	chr19	6	1		7	View
4012474	chr19	4	1		5	View
4013466	chr19	3			3	View
4014730	chr19	2			2	View
4014731	chr19	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CARD8 expression and immune infiltrating cell level correlation result in HIV+ samples
CARD8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CARD8 expression and immune infiltrating cell level correlation result in HIV+ samples
CARD8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).