HTLV1 Target gene Detail Information

> CACNA2D2 Gene Search Result

Gene Information

Gene Name	CACNA2D2
Gene ID	9254
Gene Full Name	calcium voltage-gated channel auxiliary subunit alpha2delta 2
Gene Alias	CACNA2D
Transcripts	ENSG00000007402
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	FDA approved drug targets, Predicted intracellular proteins, Transporters
Uniport_ID	Q9NY47
HGNC ID	HGNC:1400
VEGA ID	OTTHUMG00000156887
OMIM ID	607082
String ID	9606.ENSP00000418081
Drugbank ID	BE0002396; BE0004902
PharmGKB ID	PA26012

Target gene [CACNA2D2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000929	chr3	21	535	145	701	View
6002966	chr3	104	27	63	194	View
6008667	chr3	23	12	8	43	View
6023182	chr3	4			4	View
6024802	chr3	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CACNA2D2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA2D2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CACNA2D2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA2D2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of CACNA2D2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA2D2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).