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HTLV1 Target gene Detail Information

> CACNA1A Gene Search Result


Gene Information
Gene Name CACNA1A
Gene ID 773
Gene Alias BI; EA2; FHM; MHP; APCA; HPCA; MHP1; SCA6; DEE42; CAV2.1; EIEE42; CACNL1A4
Transcripts ENSG00000141837
Virus HTLV1
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID O00555
HGNC ID HGNC:1388
VEGA ID OTTHUMG00000044590
OMIM ID 601011
String ID 9606.ENSP00000353362
Drugbank ID BE0000356; BE0008717; BE0008715; BE0004902
PharmGKB ID PA26007
Target gene [CACNA1A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007050 chr19 42 18 60 View
6011157 chr19 6 21 27 View
6012993 chr19 15 5 20 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CACNA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA1A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CACNA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA1A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CACNA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
CACNA1A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).