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HIV Target gene Detail Information

> C5 Gene Search Result


Gene Information
Gene Name C5
Gene ID 727
Gene Full Name complement C5
Gene Alias C5D; C5a; C5b; ECLZB; CPAMD4
Transcripts ENSG00000106804
Virus HIV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P01031
HGNC ID HGNC:1331
VEGA ID OTTHUMG00000020579
OMIM ID 120900
String ID 9606.ENSP00000223642
Drugbank ID BE0000855
PharmGKB ID PA25911
Target gene [C5] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 33800773 N51T
Nef
C
 View
2 33800773 H116N
Nef
C
 View
3 33800773 V148L
Nef
C
 View
4 33800773 V148X
Nef
C
 View
5 33800773 M168I
Nef
C
 View
6 33800773 M168X
Nef
C
 View
7 33800773 R178G
Nef
C
 View
8 33800773 S163C
Nef
C
 View
9 33800773 I114V
Nef
C
 View

Target gene [C5] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000012 chr5 707 1294 1107 3108 View
4000064 chr16 463 401 565 1429 View
4000373 chr16 99 242 164 505 View
4000960 chr20 21 185 33 239 View
4001154 chr5 201 3 204 View
4001825 chr20 93 9 27 129 View
4002098 chr5 62 17 33 112 View
4002415 chr16 89 6 95 View
4002644 chr22 36 22 28 86 View
4002918 chr17 10 42 23 75 View
4002986 chr5 27 31 15 73 View
4003070 chr22 70 70 View
4003716 chr20 24 27 5 56 View
4004383 chr7 5 40 45 View
4004869 chr20 36 2 38 View
4005140 chr4 26 7 2 35 View
4005418 chr16 32 1 33 View
4005602 chr16 19 5 7 31 View
4005965 chr20 7 9 12 28 View
4006801 chr6 17 5 22 View
4006838 chr9 17 5 22 View
4006913 chr12 22 22 View
4007503 chr16 15 4 19 View
4007552 chr16 14 5 19 View
4008485 chr16 9 3 3 15 View
4008556 chr5 13 1 1 15 View
4009089 chr4 8 5 13 View
4009626 chr3 11 11 View
4010067 chr6 9 1 10 View
4010194 chr16 7 2 9 View
4010292 chr16 7 2 9 View
4010498 chr22 9 9 View
4010878 chr6 3 5 8 View
4011037 chr11 5 2 7 View
4011134 chr17 6 1 7 View
4011563 chr12 6 6 View
4011576 chr16 4 2 6 View
4011710 chr16 4 2 6 View
4012245 chr16 5 5 View
4012246 chr16 3 1 1 5 View
4012588 chr16 4 1 5 View
4013308 chr16 3 1 4 View
4013804 chr2 3 3 View
4014094 chr16 2 2 View
4015869 chr9 0 View
4016005 chr20 0 View
4016030 chr6 0 View
4016590 chr13 0 View
4016607 chr16 0 View
4300022 chr3 8 9 31 48 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of C5 expression and immune infiltrating cell level correlation result in HIV+ samples
C5 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of C5 expression and immune infiltrating cell level correlation result in HIV+ samples
C5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).