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HBV Target gene Detail Information

> C3 Gene Search Result


Gene Information
Gene Name C3
Gene ID 718
Gene Full Name complement C3
Gene Alias ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Transcripts ENSG00000125730
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P01024
HGNC ID HGNC:1318
VEGA ID OTTHUMG00000150335
OMIM ID 120700
String ID 9606.ENSP00000245907
Drugbank ID BE0001472; BE0003455
PharmGKB ID PA25897
Target gene [C3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000685 chr10 301 814 491 1606 View
1000743 chr19 451 1015 61 1527 View
1001124 chr19 515 334 195 1044 View
1001125 chr19 515 334 195 1044 View
1001250 chr19 362 309 195 866 View
1001831 chr2 268 99 98 465 View
1002084 chr12 67 256 28 351 View
1002091 chr12 67 254 27 348 View
1002440 chr19 154 77 45 276 View
1002535 chr19 213 34 7 254 View
1002626 chr16 63 77 96 236 View
1003425 chr19 58 37 40 135 View
1003574 chr20 115 9 124 View
1003845 chr2 97 7 1 105 View
1004773 chr19 64 3 2 69 View
1004848 chr12 46 15 6 67 View
1005204 chr11 30 29 59 View
1005292 chr20 8 15 34 57 View
1005867 chr19 42 4 46 View
1007734 chr11 11 14 25 View
1007787 chr19 24 24 View
1007788 chr19 24 24 View
1008020 chr19 16 6 1 23 View
1008645 chr4 16 4 20 View
1009075 chr8 6 11 17 View
1010489 chr16 11 1 12 View
1010844 chr11 9 2 11 View
1011067 chr11 4 6 10 View
1011806 chr12 6 2 8 View
1011844 chr12 6 2 8 View
1011874 chr12 6 2 8 View
1012320 chr12 5 2 7 View
1012323 chr12 5 2 7 View
1012343 chr12 5 2 7 View
1012956 chr12 6 6 View
1013139 chr2 2 3 5 View
1013513 chr20 5 5 View
1013647 chr20 6 2 1 9 View
1013750 chr10 4 4 View
1013822 chr10 4 4 View
1013837 chr19 2 2 4 View
1014488 chr13 2 1 3 View
1014976 chr20 3 3 View
1015468 chr10 2 2 View
1015477 chr12 2 2 View
1016081 chr8 2 2 View
1017888 chr8 0 View
1019568 chr20 0 View
1019911 chr1 0 View
1019999 chr12 0 View
1020000 chr12 0 View
1020008 chr12 0 View
1020013 chr12 0 View
1400356 chr16 2613 329 120 3062 View
1400486 chr3 19 17 12 48 View
1400512 chr2 7 1 1 9 View
1400647 chr5 11 3 1 15 View
1400648 chr5 15 9 24 View
1401373 chr13 2 1 3 View
1401563 chr2 2 3 5 View
1401612 chr8 0 View
1402208 chr10 4 4 View
1402871 chr19 42 4 46 View
1403251 chr12 46 15 6 67 View
1404666 chr19 2 2 4 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of C3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
C3 expression: Low -> High
Lollipop of C3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of C3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of C3 expression and immune infiltrating cell level correlation result in HBV+ samples
C3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).