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HPV Target gene Detail Information

> C2orf74 Gene Search Result


Gene Information
Gene Name C2orf74
Gene ID 339804
Gene Full Name chromosome 2 open reading frame 74
Transcripts ENSG00000237651
Virus HPV
Gene Type protein coding
HPA Location Info Centrosome;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID A8MZ97
HGNC ID HGNC:34439
VEGA ID OTTHUMG00000187090
String ID 9606.ENSP00000402915
PharmGKB ID PA162379547
Target gene [C2orf74] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5002728 chr2 5 3 8 View
5201083 chr2 33 1 34 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of C2orf74 expression and immune infiltrating cell level correlation result in HPV+ samples
C2orf74 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).