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HBV Target gene Detail Information

> C21orf58 Gene Search Result


Gene Information
Gene Name C21orf58
Gene ID 54058
Gene Full Name chromosome 21 open reading frame 58
Transcripts ENSG00000160298
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Nuclear bodies;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID P58505
HGNC ID HGNC:1300
VEGA ID OTTHUMG00000090634
String ID 9606.ENSP00000291691
PharmGKB ID PA25853
Target gene [C21orf58] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004609 chr21 72 3 75 View
1400842 chr21 72 3 75 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of C21orf58 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
C21orf58 expression: Low -> High
Lollipop of C21orf58 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of C21orf58 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of C21orf58 expression and immune infiltrating cell level correlation result in HBV+ samples
C21orf58 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).