HTLV1 Target gene Detail Information

> C18orf54 Gene Search Result

Gene Information

Gene Name	C18orf54
Gene ID	162681
Gene Full Name	chromosome 18 open reading frame 54
Gene Alias	LAS2
Transcripts	ENSG00000166845
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	Q8IYD9
HGNC ID	HGNC:13796
VEGA ID	OTTHUMG00000132703
OMIM ID	613258
String ID	9606.ENSP00000477654
PharmGKB ID	PA134942612

Target gene [C18orf54] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009332	chr18	36		2	38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of C18orf54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
C18orf54 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of C18orf54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
C18orf54 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of C18orf54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
C18orf54 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).