HIV Target gene Detail Information

> BTLA Gene Search Result

Gene Information

Gene Name	BTLA
Gene ID	151888
Gene Full Name	B and T lymphocyte associated
Gene Alias	BTLA1; CD272
Transcripts	ENSG00000186265
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q7Z6A9
HGNC ID	HGNC:21087
VEGA ID	OTTHUMG00000159255
OMIM ID	607925
String ID	9606.ENSP00000333919
PharmGKB ID	PA134968341

Target gene [BTLA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005285	chr3	34			34	View
4011252	chr3	5	1	1	7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of BTLA expression and immune infiltrating cell level correlation result in HIV+ samples
BTLA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of BTLA expression and immune infiltrating cell level correlation result in HIV+ samples
BTLA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).