HPV Target gene Detail Information

> BTC Gene Search Result

Gene Information

Gene Name	BTC
Gene ID	685
Gene Full Name	betacellulin
Transcripts	ENSG00000174808
Virus	HPV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	P35070
HGNC ID	HGNC:1121
VEGA ID	OTTHUMG00000130107
OMIM ID	600345
String ID	9606.ENSP00000379092
PharmGKB ID	PA25442

Target gene [BTC] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5201422	chr4	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of BTC expression and immune infiltrating cell level correlation result in HPV+ samples
BTC expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662