HBV Target gene Detail Information

> BMPR2 Gene Search Result

Gene Information

Gene Name	BMPR2
Gene ID	659
Gene Full Name	bone morphogenetic protein receptor type 2
Gene Alias	BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II
Transcripts	ENSG00000204217
Virus	HBV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q13873
HGNC ID	HGNC:1078
VEGA ID	OTTHUMG00000133617
OMIM ID	600799
String ID	9606.ENSP00000363708
Drugbank ID	BE0009292; BE0009324
Drug (Cytoscape Annotation)	Sunitinib Malate;Ruxolitinib Phosphate;Bosutinib
PharmGKB ID	PA25388

Target gene [BMPR2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004543	chr2	9	46	23	78	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of BMPR2 expression and immune infiltrating cell level correlation result in HBV+ samples
BMPR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).